Creutzfeldt-Jakob Disease, or CJD, is a very rare disease that causes spongiform of the patient's brain. Yes, this disease is extremely rare and is only found in every one in one million people world wide. This disease's symptoms mirror almost of that which is seen in a person who is suffering from dementia, so sometimes this is hard to tell the difference between a spongiform disease caused by prions and that of something like dementia or Alzheimer's. The craziest thing about CJD, is not that it mirrors that of mental deterioration disorders but that it is very elusive and the cause for it still is not confirmed. Scientists have found that this disease is very much related to an infectious form of the prion protein found in our cells. The problem though is that there is no confirmation of whether it is the actual prion that causes this disease or something else. And what brings a question to mind from this article the most to me is that 85% of mot CJD cases are labeled as sporadic CJD, meaning that this disease appears with no genetic mutation or other known risk factors that could cause this disease. The idea of this is scary! Even with a low chance in general of someone developing CJD, it is crazy to think that a large number of the cases presented that are diagnosed with CJD are of unknown origin and how contraction of the disease even occurred. In other words, for sporadic CJD scientists actually have no answer to how this happens. There are only theories, and most of the theories focus on somehow the normal prion protein in our neuronal cells change their conformation into an abnormal or "infectious" conformation that makes these prions dangerous and lead to spongiform of the brain tissues. My main question presented as the result to this article, is if it is possible that the abnormal conformation of the normal prion protein is the result of maybe a damaging chemical ingested by an individual or just a chemical that somehow reaches this prion in any way that may cause it to change its conformation. Sporadic CJD is a large mystery in the world of prions, and more research needs to be done to find the cause.
Here is the article on CJD and sporadic CJD:
http://www.ninds.nih.gov/disorders/cjd/detail_cjd.htm
This was very interesting. I had no clue that scientists had no idea what causes sporadic CJD.
ReplyDeleteThis is interesting. Do you think it could be caused by a gene mutation? ALS-FTD diseases have been lead back to a mutated gene called TDP-43 that ubiqulates into fragments that then stick together.
ReplyDeleteRose Weel is my name, I live in USA. I want to say to the whole world how my husband was cured of his Alzheimer’s disease. Brothers and Sisters, my husband is 78 years old. He is a retired US Army. He fought so many wars, and had encounter with so many dangerous diseases. Before he embarked on his last peace mission to Iraq they were administered injections that will enable them carry out their duties effectively. So they went to the battle field where he lost so many of his colleagues and also he was shot on his throat but bullets don’t have much effect on him. So after the battle he survived it and returned back to USA off course he was rewarded heavily by the government, and that lead to his retirement. But after his retirement, he began to behave funny like forgetting all he did in the past, and sometimes don’t recognize me his wife quickly. I took him to Military hospital, and the doctor said some king of liquid in his body is causing him so many reactions, and this is affecting his brain to cut the long story short, after much diagnoses using EEG, and also the test of PROTEIN 14-3-3 all pointing out to the fact that his brain has malfunction. So he was giving medicines but his condition was still becoming worse even while taking the medicines administered. So we went back to the military hospital, and he was finally diagnosed of Alzheimer’s disease and this the doctor said have no cure. So his conditions began to get worst by the day. I cried out for help, but the government only gave us financial support. I all the time surf the web looking for possible cure until I ran into a blog where a man named James Watt gave testimony on how his cousin was cured of CJD by an herbal doctor called Doctor Uwadia Amenifo. In his testimony he imputed the contact detail of the herbalist. So I quickly copied out the contact details of Uwadia, and I contacted him immediately and explained to him what my husband is going through. He encouraged me and promised me that surly he will cure my husband, so after all necessary arrangement was made; he prepared the herbal medicine, and shipped it to me in USA, so I followed his instructions, and gave the medicine to my husband. Behold just like a magic in my eyes my husband was responding positively to the medicine and in just less than 3 weeks I started giving him the medicine, he was very okay, and in less than 7 weeks my husband was totally curd, and as I speak to you now my husband is totally cured, and he is now very okay, and in good health. So please all here shall help me say a big thanks to Doctor Uwadia Amenifo for helping me cure my husband of his Alzheimer’s disease. Please if you need Doctor Uwadia’s contact details, here is it. Email (doctoruwadiaamenifo@gmail.com) and his number is (+2349052015874). God bless all.
ReplyDeleteI am happy because today i am a living testimony. i want all here to know how i was cured of my CJD. i was diagnosed of CJD some months back. And my health begins to deteriorate gradually. It got to the extent that the symptoms was now all over my body. i have spent thousands of $$ in search for a cure but my doctor keep telling me no cure. i almost gave up. But on a very faithful day as my daughter was browsing on the internet, she saw someone who testified of how a herbal doctor by the name Doctor Ehidiamen cured him of his disease with the use of herbs. So she tried to get in contact with this doctor, and after she explain to him, he assured her that he can cure me of my CJD. He gave me the steps to follow, i followed it and he prepared the herbs and send it to me in USA. i took the mixture according to his prescription and behold it worked perfectly for me. Today i am happy to say i totally cured of my CJD and my family is happy together again. Please i want you all suffering from CJD, or other brain related problem to also get cured just as i was cured. for this reason i want you all to contact the herbal doctor Ehidiamen. His email is email is: doctorehidiamen@gmail.com and his phone number is +2348146942481. Just explain to him what you are passing through and get his counsel and treatment. Thanks to you all.
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